Research area

     1)Telomere rejuvenation, maintenance and regulation and mechanisms in pluripotent stem cells (ES/iPS/CiPS cells) and cancer stem cells

     2)Mechanisms of ovarian aging and anti-ovarian aging

Research highlight:

  • Feeder Cells Regulate Telomere Homeostasis and Pluripotency Maintenance of Mouse Embryonic Stem Cells (Nature communication, 2018)

  • Pold3 is required for genomic stability and telomere integrity in embryonic stem cells and meiosis (Nucleic Acids Research, 2018)
  • Schematic diagram illustrating the process of CiPSC induction following addition of crotonic acid, which activates 2C genes including Zscan4, reduces telomere and DNA damage, and maintains telomeres, promoting CiPSC formation (Stem Cell Reports, 2018)

  • Simultaneous measurement of telomere length and transcriptome in the same cell (BMC Biology, 2017)

  • Telomere Reprogramming Links to Somatic Cell Reprogramming and Stem Cell Pluripotency (Trends in Genetics, 2017)
  • Tet Enzymes Regulate Telomere Maintenance and Chromosomal Stability of Mouse ESCs (Cell reports, 2016)

  • Original iPS technology reprograms telomeres gradually
    Fully reprogramming of telomere length is required for naïve pluripotency of iPS cells
    iPS
    induction efficiency and quality can be significantly improved by Zscan4 which lengthens telomeres rapidly and prevents genomic damage图片2
  • Short telomeres in ESCs up-regulate 2-cell stage genes including Zscan4, compensating for telomere shortening,and affecting differentiation. 图片3
  • Telomere elongation and naïve pluripotency of telomerase haplo-insufficient cells (Terc+/-) by SCNT clone technology

  • 图片4

  • Ovarian senescence and Potential therapy 图片5
  • Degradation of cohesin in oocytes with maternal age图片6
  • Ovarian aging in monkeys is associated with reduced numbers of germ cells (DDX4/VASA) and follicles 图片7
  • Unlike adult testis with continuous spermatogenesis marked by SCP3 homologous pairing synapsis mediated by telomeres, absence of neo-oogenesis in adult monkey ovaries links to ovarian senescence with age 图片8图片9图片10图片11图片12
    • Generation and conversion of chemically induced iPS
    • Small molecules and three dimension for optimization of ES cultures and differentiation
    • Epigenetic compounds for rejuvenation of telomere and anti-aging
    • Small molecules to target to telomeres and cancer stem cells