1)      Feeders facilitate telomere maintenance and chromosomal stability of embryonic stem cells. Nat Commun. 2018 Jul 5;9(1):2620. doi: 10.1038/s41467-018-05038-2.

Guo RP, Ye XY, Yang J, Zhou ZC, Tian CL, Wang H, Wang HY, Fu HF, Liu C, Zeng M, Yang J & Liu L.

2)      Dynamics of Telomere Rejuvenation during Chemical Induction to Pluripotent Stem Cells. Stem Cell Reports. 2018 July 10. 11(1): 70-87. doi: 10.1016/j.stemcr.2018.05.003. 

Fu H, Tian CL, Ye X, Sheng X, Wang H, Liu Y, Liu L.

3)      Pold3 is required for genomic stability and telomere integrity in embryonic stem cells and meiosis. Nucleic Acids Res. 2018 Apr 20;46(7):3468-3486. doi: 10.1093/nar/gky098. 

Zhou Z, Wang L, Ge F, Gong P, Wang H, Wang F, Chen L, Liu L.

4)      Telomere heterogeneity linked to metabolism and pluripotency state revealed by simultaneous analysis of telomere length and RNA-seq in the same human embryonic stem cell. BMC Biol. 2017 Dec 8;15(1):114. doi: 10.1186/s12915-017-0453-8. 

Wang H, Zhang K, Liu Y, Fu Y, Gao S, Gong P, Wang H, Zhou Z, Zeng M, Wu Z, Sun Y, Chen T, Li S, Liu L.

5)      Overexpression of Hdac6 extends reproductive lifespan in mice. Protein Cell. 2017 May;8(5):360-364. doi: 10.1007/s13238-017-0375-9.

Zhang X, Yang J, Wang H, Guo R, Yin Y, Zhang D, Zhang Q, Wang H, Zhou Z, Chen L, Zhou J, Liu L.

6)      Linking Telomere Regulation to Stem Cell Pluripotency. Trends Genet. 2017 Jan;33(1):16-33. doi: 10.1016/j.tig.2016.10.007. Epub 2016 Nov 23. Review.

Liu L.

7)      Tet Enzymes Regulate Telomere Maintenance and Chromosomal Stability of Mouse ESCs. Cell Rep. 2016 May 24;15(8):1809-21. doi: 10.1016/j.celrep.2016.04.058. 

Yang J, Guo R, Wang H, Ye X, Zhou Z, Dan J, Wang H, Gong P, Deng W, Yin Y, Mao S, Wang L, Ding J, Li J, Keefe DL, Dawlaty MM, Wang J, Xu G, Liu L.

8)      Epigenetic Modifiers Facilitate Induction and Pluripotency of Porcine iPSCs. Stem Cell Reports. 2017 Jan 10;8(1):11-20. doi: 10.1016/j.stemcr.2016.11.013.

Mao J, Zhang Q, Deng W, Wang H, Liu K, Fu H, Zhao Q, Wang X, Liu L.

9)      Erk signaling is indispensable for genomic stability and self-renewal of mouse embryonic stem cells. Proc Natl Acad Sci U S A. 2015 Nov 3;112(44):E5936-43. doi: 10.1073/pnas.1516319112.

Chen H, Guo R, Zhang Q, Guo H, Yang M, Wu Z, Gao S, Liu L, Chen L.

10)   BRCA Mutations, DNA Repair Deficiency, and Ovarian Aging. Biol Reprod. 2015 Sep;93(3):67. doi: 10.1095/biolreprod.115.132290.

Oktay K, Turan V, Titus S, Stobezki R, Liu L.

11)   Overexpression of Hdac6 enhances resistance to virus infection in embryonic stem cells and in mice. Protein Cell. 2015 Feb;6(2):152-6. doi: 10.1007/s13238-014-0120-6.

Wang D, Meng Q, Huo L, Yang M, Wang L, Chen X, Wang J, Li Z, Ye X, Liu N, Li Q, Dai Z, Ouyang H, Li N, Zhou J, Chen L, Liu L.

12)   Telomere Elongation and Naive Pluripotent Stem Cells Achieved from Telomerase Haplo-Insufficient Cells by Somatic Cell Nuclear Transfer.  Cell reports, 9, 5, 1603-1609, 2014

Sung, Li-Ying, Chang, Wei-Fang, Zhang, Qian, Liu, Chia-Chia, Liou, Jun-Yang, Chang, Chia-Chun, Ou-Yang, Huan, Guo, Renpeng, Fu, Haifeng, Cheng, Winston T K, Ding, Shih-Torng, Chen, Chuan-Mu, Okuka, Maja, Keefe, David L, Chen, Y Eugene, Liu, Lin, Xu, Jie

13)   Generation of iPS Cells from Granulosa Cells.  Methods in molecular biology (Clifton, N.J.), 0, 0, , 2014

Mao, Jian, Liu, Lin

14)   Drp1 is dispensable for mitochondria biogenesis in induction to pluripotency but required for differentiation of embryonic stem cells. Stem cells and development, 23, 20, 2422-34, 2014

Wang, Lei, Ye, Xiaoying, Zhao, Qiang, Zhou, Zhongcheng, Dan, Jiameng, Zhu, Yushan, Chen, Quan, Liu, Lin

15)   Telomere Length Maintenance, Shortening, and Lengthening.  J Cell Physiol, 229, 10, 1323-9, 2014

Zhao Z, Pan X, Liu L, Liu N

16)   Single-cell analysis of the transcriptome and its application in the characterization of stem cells and early embryos.  Cell Mol Life Sci, 71, 14, 2707-15, 2014

Liu N, Liu L, Pan X

17)   Knockdown of H19 enhances differentiation capacity to epidermis of parthenogenetic embryonic stem cells.  Current Molecular Medicine, 14, 6, 737-48, 2014

Yin Y, Wang H, Liu K, Wang F, Ye X, Liu M, Xiang R, Liu N, Liu L

18)   Telomere Elongation Facilitated by Trichostatin A in Cloned Embryos and Pigs by Somatic Cell Nuclear Transfer.  Stem Cell Rev, 10, 3, 399-407, 2014

Kong Q, Ji G, Xie B, Li J, Mao J, Wang J, Liu S, Liu L, Liu Z

19)   Rif1 Maintains Telomere Length Homeostasis of ESCs by Mediating Heterochromatin Silencing.  Dev Cell, 29, 1, 7-19, 2014

Dan J, Liu Y, Liu N, Chiourea M, Okuka M, Wu T, Ye X, Mou C, Wang L, Yin Y, Yuan J, Zuo B, Wang F, Li Z, Pan X, Yin Z, Chen L, Keefe DL, Gagos S, Xiao A, Liu L

20)   Efficient induction of pluripotent stem (iPS) cells from granulosa cells by Oct4 and Sox2.  Stem Cells and Development, 23, 7, 779-789, 2014

J Mao, Q Zhang, X Ye, K Liu, L Liu

21)   Telomere elongation in parthenogenetic stem cells.  Protein Cell, 5, 1, 8-11, 2014

Yin Y, Liu N, Ye X, Guo R, Hao J, Wang F, Liu L

22)   Roles for Tbx3 in regulation of two-cell state and telomere elongation in mouse ES cells.  Sci Rep, 13, 3, 3492, 2013

Dan J, Li M, Yang J, Li J, Okuka M, Ye X, Liu L

23)   No evidence for neo-oogenesis may link to ovarian senescence in adult monkey. Stem Cells, 31, 11, 2538-2550, 2013

Yuan J, Zhang D, Wang L, Liu M, Mao J, Yin Y, Ye X, Liu N, Han J, Gao Y, Cheng T, Keefe DL, Liu L

24)   Robust measurement of telomere length in single cells.  Proc Natl Acad Sci USA, 110, 21, E1906-1912, 2013

Wang F, Pan X, Kalmbach K, Seth-Smith ML, Ye X, Antumes DM, Yin Y, Liu L, Keefe DL, Weissman

25)   Resveratrol protects against age-associated infertility in mice. Human Reproduction, 28, 3, 707-717, 2013

Liu M, Yin Y, Ye X, Zeng M, Zhao Q, Keefe DL, Liu L

26)   Transplantation of parthenogenetic embryonic stem cells ameliorates cardiac dysfunction and remodelling after myocardial infarction. Cardiovascular Research, 97, 2, 208-218, 2013

Liu Y, Ye X, Mao L, Cheng Z, Yao X, Jia X, Mao D, Ou L, Li Z, Che Y, Liu N, Steinhoff G, Liu L, Kong D

27)   Reprogramming- and pluripotency-associated membrane proteins in mouse stem cells revealed by label-free quantitative proteomics. Journal of Proteomics, 86, 0, 70-84, 2013

Hao J, Li W, Dan J, Ye X, Wang F, Zeng X, Wang L, Wang H, Cheng Y, Liu L, Shui W

28)   Piglets cloned from induced pluripotent stem cells.  Cell Research, 23, 1, 162-166, 2013

Fan N, Chen J, Shang Z, Dou H, Ji G, Zou Q, Wu L, He L, Wang F, Liu K, Liu N, Han J, Zhou Q, Pan D, , Zhao B, Ouyang Z, Liu Z, Zhao Y, Lin L, Zhong C, W, Wang S, Xu Y, Luan J, Liang Y, Yang Z, Li J, Lu C, Vajta G, Li Z, Ouyang H, Wang H, Wang Y, Yang Y, Liu Z, Wei H, Luan Z, Esteban MA, Deng H, Yang H, Pei D, Li N, Pei G, Liu L, Du Y, Xiao L, Lai L

29)   Zscan4 promotes genomic stability during reprogramming and dramatically improves the quality of iPS cells as demonstrated by tetraploid complementation.  Cell Research, 23, 1, 92-106, 2013

Jiang J, Lv W, Ye X, Wang L, Zhang M, Yang H, Okuka M, Zhou C, Zhang X, Liu L, Li J

30)   Telomere shortening and DNA damage of embryonic stem cells induced by cigarette smoke.  Reproductive Toxicology, 35, 0, 89-95, 2013

Huang J, Okuka M, Lu W, Tsibris JC, McLean MP, Keefe DL, Liu L

31)   Isolation and culture of bovine embryonic stem cells.  Methods Mol Biol, 1074, 0, 111-123, 2013

Cao S, Wang F, Liu L

32)   Association of telomere instability with senescence of porcine cells. BMC Cell Biology, 15, 13, 36, 2012

Ji G, Liu K, Okuka M, Liu N, Liu L

33)   Conservation and characterization of unique porcine interstitial telomeric sequences.  Sci China Life Sci, 55, 12, 1029-1037, 2012

Ji G, Liu K, Chen C, Ruan W, Glytsou C, Yang Y, Okuka M, Song W, Gagos S, Li N, Liu L

34)   Generation of porcine-induced pluripotent stem cells by using OCT4 and KLF4 porcine factors.  Cell Reprogram, 14, 6, 505-513, 2012

Liu K, Ji G, Mao J, Liu M, Wang L, Chen C, Liu L.

35)   Influences of lamin A levels on induction of pluripotent stem cells. Biology Open, 1, 11, 1118-1127, 2012

Zuo B, Yang J, Wang F, Wang L, Yin Y, Dan J, Liu N, Liu L

36)   Delay in oocyte aging in mice by the antioxidant N-acetyl-L-cysteine (NAC). Hum Reproduction, 27, 5, 1411-2140, 2012

Liu J, Liu M, Ye X, Liu K, Huang J, Wang L, Ji G, Liu N, Tang X, Baltz JM, Keefe DL, Liu L

37)   Molecular insights into the heterogeneity of telomere reprogramming in induced pluripotent stem cells.  Cell Research, 22, 4, 757-768, 2012

Wang F, Yin Y, Ye X, Liu K, Zhu H, Wang L, Chiourea M, Okuka M, Ji G, Dan J, Zuo B, Li M, Zhang Q, Liu N, Chen L, Pan X, Gagos S, Keefe DL, Liu L

38)   Parthenogenetic Activation-Induced Pluripotent Stem Cells and Potential Applications.  Stem Cells and Cancer Stem Cells, 8, 0, 235-246, 2012

Yu Yin , Na Liu , David L. Keefe , and L Liu

39)   Isolation and Maintenance of Murine Embryonic Stem Cells.  Stem Cell Biology Basic Concepts to Frontiers, 0, 0, 26-85, 2012

Junjiu Huang, Fang Wang, Xiaoying Ye, Jinmao Liu, David L. Keefe and L Liu

40)   Epigenetic Regulation in Pluripotent Stem Cells.  Advances in Molecular Biology and Medicine, 0, 0, 563-600, 2011

Liu L. and Chen LY

41)   Mouse embryos stressed by physiological levels of osmolarity become arrested in the late two-cell stage before entry into M-phase.  Biology of Reproduction, 85, 4, 702-713, 2011

Wang F, Kooistra M, Lee M, Liu L, Baltz JM

42)   Quantitative proteomics analysis of parthenogenetically induced pluripotent stem cells.  Protein Cell, 2, 8, 631-46, 2011

Hu Z, Wang L, Xie Z, Zhang X, Feng D, Wang F, Zuo B, Wang L, Liu Z, Chen Z, Yang F, Liu L

43)   Isolation of mouse mesenchymal stem cells with normal ploidy from bone marrows by reducing oxidative stress in combination with extracellular matrix. BMC Cell Biol, 12, 1, 30, 2011

Fan G, Wen L, Li M, Li C, Luo B, Wang F, Zhou L, Liu L

44)   Association of telomere length with authentic pluripotency of ES/iPS cells. Cell Res, 21, 5, 779-792, 2011

Huang J, Wang F, Okuka M, Liu N, Ji G, Ye X, Zuo B, Li M, Liang P, Ge WW, Tsibris JC, Keefe DL, Liu L

45)   Germline competency of parthenogenetic embryonic stem cells from immature oocytes of adult mouse ovary.  Hum Mol Genet, 20, 7, 1339-1352, 2011

Liu Z, Hu Z, Pan X, Li M, Togun TA, Tuck D, Pelizzola M, Huang J, Ye X, Yin Y, Liu M, Li C, Chen Z, Wang F, Zhou L, Chen L, Keefe DL, Liu L

46)   Genome-wide gene expression profiling reveals aberrant MAPK and Wnt signaling pathways associated with early parthenogenesis.  Journal of molecular cell biology, 2, 6, 333-44, 2010

Liu N, Enkemann SA, Liang P, Hersmus R, Zanazzi C, Huang J, Wu C, Chen Z, Looijenga LH, Keefe DL, Liu L

47)   Telomere susceptibility to cigarette smoke-induced oxidative damage and chromosomal instability of mouse embryos in vitro.  Free Radical Biology & Medicine, 48, 12, 1663-1676, 2010

Huang J, Okuka M, McLean M, Keefe DL, Liu L

48)   Generation of pluripotent stem cells from eggs of aging mice.  Aging Cell, 9, 2, 113-125, 2010

Huang J, Okuka M, Wang F, Zuo B, Liang P, Kalmbach K, Liu L, Keefe DL

49)   Rescue of postcompaction-stage mouse embryo development from hypertonicity by amino acid transporter substrates that may function as organic osmolytes.  Biology of reproduction, 82, 4, 769-777, 2010

Richards T, Wang F, Liu L, Baltz JM

50)   Telomere elongation in induced pluripotent stem cells from dyskeratosis congenita patients.  Nature, 464, 7286, 292-6, 2010

Agarwal S, Loh YH, McLoughlin EM,, Huang J, Park IH, Miller JD, Huo H,, Okuka M, Dos Reis RM, Loewer S,, Ng HH, Keefe DL, Goldman FD,, Klingelhutz AJ, Liu L, Daley GQ

51)   Effects of cigarette smoke on fertilization and embryo development in vivo. Fertility and Sterility, 92, 4, 1456-1465, 2009

Huang J, Okuka M, McLean M, Keefe DL, Liu L

52)   Birth of Parthenote Mice Directly from Parthenogenetic Embryonic Stem Cells.  Stem Cells, 27, 9, 2136-2145, 2009

Chen Z, Liu Z, Huang J, Amano T, Li C, Cao S, Wu C, Liu B, Zhou L, Carter MG, Keefe DL, Yang X, Liu L

53)   Current progress and prospects of induced pluripotent stem cells . Sci China C Life Sci, 52, 7, 622-636, 2009

Chen L, Liu L

54)   Correlation of expression and methylation of imprinted genes with pluripotency of parthenogenetic embryonic stem cells.  Human Molecular Genetics, 18, 12, 2177-87, 2009

Li C, Chen Z, Liu Z, Huang J, Zhang W, Zhou L, Keefe DL, Liu L

55)   Isolation and culture of primary bovine embryonic stem cell colonies by a novel method.  Journal of experimental zoology. Part A, Ecological genetics and physiology, 311, 5, 368-76, 2009

Cao S, Wang F, Chen Z, Liu Z, Mei C, Wu H, Huang J, Li C, Zhou L, Liu L

56)   Exogenous Nanog alleviates but is insufficient to reverse embryonic stem cells differentiation induced by PI3K signaling inhibition.  Journal of Cellular Biochemistry, 106, 6, 1041-1047, 2009

Liu N, Lu M, Feng XM, Ma FX, Fang ZH, Tian XM, Ren Q, Zhang L, Liu B, Huang PP, Liu L, Han ZC

57)   Telomeres and reproductive aging.  Reproduction, Fertility and Development, 21, 1, 10-14, 2009

Keefe DL, Liu L

58)   Defective cohesin is associated with age-dependent misaligned chromosomes in oocytes.  Reprod Biomed Online, 16, 1, 103-112, 2008

Liu L, Keefe DL

59)   Efficient production of mice from embryonic stem cells injected into four- or eight-cell embryos by piezo micromanipulation.  Stem Cells, 26, 7, 1883-1890, 2008

Huang J, Deng K, Wu H, Liu Z, Chen Z, Cao S, Zhou L, Ye X, Keefe DL, Liu L

60)   Haploinsufficiency of Parp1 accelerates Brca1-associated centrosome amplification, telomere shortening, genetic instability, apoptosis, and embryonic lethality.  Cell Death & Differentiation, 14, 5, 926-931, 2007

Wang X, Liu L, Montagna C, Ried T, Deng CX

61)   Telomeres and aging-related meiotic dysfunction in women.  Cellular and Molecular Life Sciences, 64, 2, 139-143, 2007

Keefe DL, Liu L, Marquard K

62)   Telomere lengthening early in development.  Nature Cell Biology, 9, 12, 1436-1441, 2007

Liu L, S. M. Bailey, M. Okuka, P. Muñoz, C. Li, L. Zhou, C. Wu, E. Czerwiec, L. Sandler, A. Seyfang, M. A. Blasco and Keefe. D. L

63)   Germline stem cells and neo-oogenesis in the adult human ovary. Developmental Biology, 306, 1, 112-120, 2007

Liu Y, Wu C, Lyu Q, Yang D, Albertini DF, Keefe DL, Liu L

64)   Chapter 15 Nuclear Transfer Methods to Study Aging.  Methods in Molecular Biology: Biological Aging: Methods and Protocols, 0, 0, 191-207, 2007

Liu L, Keefe DL